Yesterday the journal PLoS Medicine published a study which combined the results of 47 trials on some anti-depressant drugs, including Prozac, and found only minimal benefits over placebo, except for the most depressed patients. It has been misreported as a definitive nail in the coffin: this is not true. It was a restricted analysis but, more important, on the question of antidepressants, it added very little. We already knew SSRIs give only a modest benefit in mild and moderate depression and, indeed, the Nice guidelines themselves have actively advised against using them in milder cases.
Link to Article
Additional Stories
The creation of the Prozac myth - The Guardian 27th February 2008
The drug industry's long and ignoble history of secrecy - The Independent 27th February 2008
Forcing drug companies to publish negative trial results ‘is against law’ - The Times 27th February 2008
Forcing drug companies to publish negative trial results ‘is against law’ - The Times 27th February 2008
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